New conjugates for the introduction of nucleic acid into...

Details New conjugates for the introduction of nucleic acid into... New conjugates for the introduction of nucleic acid into...

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/08 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2114800

- 56 - Abstract Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalised in the cell, possibly with the co-operation of a cell-type-specific internalising factor, whilst the virus as part of the complex brings about the internalisation and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy, and transfection kits.

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