New controlled release bead, a method of producing the same...

A - Human Necessities – 61 – K

Patent

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167/164, 167/275

A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) A61K 9/58 (2006.01) A61K 9/70 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61P 1/00 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2350061

A controlled release bead comprises: (i) a core unit of a substantially water- soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.

L'invention concerne un comprimé à libération contrôlée qui comprend: I) un noyau composé d'une matière inerte qui se dissout ou gonfle dans l'eau de façon importante; ii) une première couche appliquée sur ce noyau et composée d'un polymère considérablement insoluble dans l'eau; iii) une seconde couche appliquée sur la première couche et contenant un principe actif; et iv) une troisième couche appliquée sur la seconde couche et composée d'un polymère intervenant dans la libération contrôlée du principe actif, la première couche étant conçue pour réguler l'infiltration de l'eau dans le noyau. Une méthode de production du comprimé à libération contrôlée est également décrite.

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