C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 273/08 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) C07D 273/00 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2223828
The present invention provides novel cryptophycin compounds having structure (I). The present invention also provides methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using novel cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.
L'invention concerne de nouveaux composés de cryptophycine ayant la formule (I), des procédés pour produire ces nouvelles cryptophycines à partir d'algues bleu-vert (cyanobactéries) du genre Nostoc sp., des compositions pharmaceutiques contenant les nouvelles cryptophycines, et des procédés d'utilisation des nouvelles cryptophycines pour inhiber la prolifération de cellules hyperprolifératives, en particulier de cellules hyperprolifératives présentant des phénotypes ayant développé une résistance aux médicaments, et pour traiter des pathologies telles que les néoplasies.
Corbett Thomas H.
Golakoti Trimurtulu
Mooberry Susan L.
Moore Richard E.
Patterson Gregory M.l.
Sim & Mcburney
University Of Hawai'i
Wayne State University
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