New cryptophycins from synthesis

Details New cryptophycins from synthesis New cryptophycins from synthesis

C - Chemistry, Metallurgy

07

D

C07D 273/00 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) A61K 38/15 (2006.01) C07D 257/02 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07F 9/6524 (2006.01) C07F 9/6527 (2006.01) C07F 9/6574 (2006.01) C07K 5/023 (2006.01) C07K 11/00 (2006.01)

Patent

CA 2214565

Novel cryptophycin compounds are disclosed, together with methods of producing cryptophycins by total synthesis and methods for the use of such cryptophycins in pharmaceuticals to inhibit the proliferation of mammalian cells and to treat neoplasia.

L'invention concerne de nouveaux composés de cryptophycines ainsi que des procédés de production de cryptophycines obtenus par synthèse totale. L'invention traite également de procédés d'utilisation de ces cryptophycines comme produits pharmaceutiques pour inhiber la prolifération des cellules de mammifères et pour traiter les néoplasies.

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