C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/58 (2006.01) A61K 31/381 (2006.01) A61P 11/06 (2006.01)
Patent
CA 2642216
Crystalline forms of (+)-R-zileuton, which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of (+)-R- zileuton are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline (+)-R-zileuton, and using it to inhibit 5-lipoxygenase activity in subjects to treat a number of diseases, are also discussed.
L'invention porte sur des formes cristallines de (+)-R-zileuton qui peuvent être utilisées dans des applications pharmaceutiques. Des formes cristallines spécifiques de (+)-R-zileuton se caractérisent par diverses propriétés et mesures physiques. L'invention porte également sur des procédés de production de (+)-R-zileuton cristallin et sur son utilisation pour inhiber l'activité de la 5-lipoxygénase chez des sujets en vue de traiter certaines maladies.
Cornerstone Therapeutics Inc.
Critical Therapeutics Inc.
Gowling Lafleur Henderson Llp
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