C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/551 (2006.01) A61P 25/06 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2648140
The invention relates to the novel crystalline compounds A of general formula (I), wherein A1, A2, A3, X, Y1, Y2, and Y3 are defined as indicated in claim 1, and which are provided in the form of the physiologically acceptable salts thereof with acids, said acids being selected among group B comprising hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, benzenesulfonic acid, p-toluenesulfonic acid, maleic acid, succinic acid, fumaric acid, D-(-)-tartaric acid, L-(+)-tartaric acid, naphthalene-2-sulfonic acid, and naphthalene-1,5-disulfonic acid, as well as the polymorphs, the respective solvates and hydrates.
La présente invention concerne de nouveaux composés cristallins A de formule générale (I) dans laquelle A<SUP>1</SUP>, A<SUP>2</SUP>, A<SUP>3</SUP>, X, Y<SUP>1</SUP>, Y<SUP>2</SUP> et Y<SUP>3</SUP> ont les correspondances indiquées dans la revendication 1, et leurs sels tolérés d'un point de vue physiologique, avec des acides qui sont choisis dans la groupe B qui comprend l'acide chlorhydrique, l'acide bromhydrique, l'acide sulfurique, l'acide phosphorique, l'acide benzène-sulfonique, l'acide p-toluène-sulfonique, l'acide maléique, l'acide succinique, l'acide fumarique, l'acide tartrique dextrogyre, l'acide tartrique lévogyre, l'acide naphthaline-2-sulfonique et l'acide naphthaline-1,5-disulfonique, ainsi que leurs formes polymorphes, et les solvates et hydrates correspondants.
Huchler Guenther
Ries Uwe
Sproll Sonja
Werthmann Ulrike
Zopf Andreas
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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