New cxcr2 inhibitors

Details New cxcr2 inhibitors New cxcr2 inhibitors

A - Human Necessities

61

K

A61K 31/166 (2006.01) A61P 29/00 (2006.01) C07C 235/66 (2006.01) C07D 213/30 (2006.01) C07D 215/24 (2006.01) C07D 333/64 (2006.01)

Patent

CA 2656150

The invention relates to compounds of the formula (I), in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.

L'invention concerne des composés de formule (I), dans laquelle R1, R2, X, A, B, Z et Y1 à Y4 ont les significations indiquées dans les revendications, et/ou un de leurs sels pharmaceutiquement acceptables et/ou un de leurs promédicaments. Parce qu'ils ont des propriétés comme inhibiteurs des récepteurs de chimiokine, en particulier comme inhibiteurs de CXCR2, les composés de la formule (I) et leurs sels et promédicaments pharmaceutiquement acceptables conviennent à la prévention et au traitement de maladies médiées par la chimiokine.

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