New cytotoxic tris(oxazole)-containing macrolides

Details New cytotoxic tris(oxazole)-containing macrolides New cytotoxic tris(oxazole)-containing macrolides

C - Chemistry, Metallurgy

07

D

C07D 498/22 (2006.01) A61K 31/424 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2319032

HA-1 and TH-2, two novel cytotoxic tris(oxazole)-containing macrolides, have been shown. These compounds have been obtained by chemical modification of marine natural products. IU structure of these compounds has been established on the basis of NMR data.

L'invention concerne deux nouveau macrolides cytotoxiques renfermant du trio(oxazole), HA-1 et TH-2. Ces composés sont le résultat de modification chimique de produits naturels marins. On a établi la structure de ces composés sur la base de données RMN.

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