New derivatives of fluorinated benzothiadiazines, the...

C - Chemistry – Metallurgy – 07 – D

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C07D 285/24 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2492161

This invention relates to compounds of formula (I): (See formula I) wherein: ~ RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, ~ R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, ~ R2 represents hydrogen, halogen or a group selected from cycloalkyl and optionally substituted alkyl, ~ R3 to R6, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, nitro, cyano, alkylsulphonyl, hydroxy, alkoxy, optionally substituted alkyl and optionally substituted amino, its optical isomers when they exist, and also their addition salts with a pharmaceutically acceptable acid or base. This invention relates to the use of compounds of formula (I): and the pharmaceutical compounds contained therein.

L'invention concerne un composé de formule (I) : (voir formule I) dans laquelle : ~ R F représente un groupement mono- ou poly- fluoroalkyle, ou monofluoro- ou polyfluoro--cycloalkylalkyle, ~ R1 représente un atome d'hydrogène ou un groupement choisi parmi alkylaminocarbonyle et alkyle éventuellement substitué, ~ R2 représente un atome d'hydrogène ou d'halogène ou un groupement choisi parmi cycloalkyle et alkyle éventuellement substitué, ~ R3 à R6, identiques ou différents, représentent chacun un atome ou un groupement choisi parmi les atomes d'hydrogène, d'halogène et les groupements nitro, cyano, alkylsulfonyle, hydroxy, alkoxy, alkyle éventuellement substitué, et amino éventuellement substitué, ainsi que leurs sels d'addition avec un acide ou une base pharmaceutiquement acceptable, et leurs isomères optiques lorsqu'ils existent. L'invention concerne également l'utilisation des composés de formule (I) et les compositions pharmaceutiques qui les contiennent.

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