C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/60 (2006.01) A61K 31/16 (2006.01) C07C 237/22 (2006.01)
Patent
CA 2211342
The invention relates to new derivatives of glycylanilides having general formula (I), wherein, particularly, R¿1?, R¿3?, R¿4?, R¿8?, R¿9? represent CH¿3?; R¿2?, R¿5?, R¿6?, R¿7? represent H; R¿10? represents C¿12?H¿25? and A is a sulfur atom. It also relates to the preparation process and the pharmaceutical compositions comprising as active principle at least one of said compounds, as well as the utilization of said derivatives for the fabrication of drugs intended to the treatment of hypercholesterolemy or atherosclerosis.
L'invention concerne de nouveaux dérivés de glycylanilides de formule générale (I), dans laquelle, en particulier: R1, R3, R4, R8, R9 représentent CH3; R2, R5, R6, R7 représentent H; R10 représente C12H25 et A est un atome de soufre. Elle concerne également leur procédé de préparation et les compositions pharmaceutiques comprenant à titre de principe actif au moins un de ces composés, ainsi que l'utilisation de ces dérivés pour la fabrication de médicaments destinés au traitement de l'hypercholestérolémie ou de l'athérosclérose.
Autin Jean-Marie
Delhon Andre
Oms Philippe
Patoiseau Jean-Francois
Ogilvy Renault
Pierre Fabre Medicament
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