C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/409 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2587328
The invention relates to derivatives of porphyrin, particularly chlorins and/or bacteriochlorins, having formula (I) and (II), which can be used in photodynamic therapy. According to the invention, X1, X2, X3, X4, X5, X6, X7, X8, which may be identical or different, each represent halogen atoms or hydrogen atoms, and R1, R2, R3, R4, which may be identical or different, are each selected from the following groups: -OH, amino acids, -OR and -NHR and/or a chlorine atom, wherein R is an alkyl group having between 1 and 12 carbon atoms. The invention also relates to an anticancer and/or antiviral and/or antimicrobial medicament for human or animal use, which contains one or more compounds as the main active ingredient.
La présente invention concerne des dérivés de porphyrine, notamment chlorines et/ou bactériochlorines, de formule (I) et (II) utiles en thérapie photodynamique. Selon l'invention- X1, X2, X3, X4, X5, X6, X7, X8 sont chacun, identiques ou différents, soit des atomes d'halogène, soit des atomes d'hydrogène; - R1, R2, R3, R4 sont chacun, identiques ou différents, choisis parmi les groupements : -OH, acides aminés, -OR et -NHR et/ou atome de chlore, dans lesquels R est un groupement alkyle ayant de 1 à 12 atomes de carbone. La présente invention concerne également un médicament anti-cancéreux et/ou antiviral et/ou antimicrobien à usage humain ou animal présentant comme principe actif principal un ou plusieurs composés.
Arnaut Moreira Luis Guilherme
Formosinho Simoees Sebastiaeo Jose
Miguens Pereira Maria
Monteiro Carlos
Mcfadden Fincham
Universidade de Coimbra
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