New dna polymerase inhibitors, mikanolide and dihydromikanolide

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/365 (2006.01) A61K 6/00 (2006.01) A61K 31/343 (2006.01) A61P 31/12 (2006.01) A61P 33/02 (2006.01) A61P 33/06 (2006.01) A61P 35/00 (2006.01) C07D 493/22 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2393056

The invention concerns DNA polymerase inhibitors, namely mikanolide and dihydromikanolide and dihydromikanolide-enriched extracts. Said compounds or mixtures can be used for preparing medicines designed to treat proliferative diseases, in particular cancer, viral diseases or parasitic diseases provoked by protozoae (for example malaria ) or protists (for example, diseases caused by amoebae).

La présente invention concerne des inhibiteurs des ADN polymérases, à savoir le mikanolide, le dihydromikanolide et des extraits enrichis en dihydromikanolide. Ces composés ou mélanges peuvent être utilisés pour préparer des médicaments destinés à traiter des maladies prolifératives, notamment le cancer, des maladies virales ou des maladies parasitaires causées par des protozoaires (par exemple la malaria) ou des protistes (par exemples les maladies causées par les amibes).

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