C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/12 (2006.01) A61K 31/415 (2006.01) A61K 51/04 (2006.01) A61P 25/28 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2726999
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from -C(R1)(R2)- , -C(R3)=, -N(R4)-, -N=, -N(R5)=, -O- and -S-; M and Z are independently nondirectionally selected from formula (I) and formula (II).
La présente invention concerne un compose représenté par la formule (E). La présente invention concerne également un composé représenté par la formule (E) destiné à être utilisé dans le traitement de maladies liées à lagrégation des protéines et/ou des maladies neurodégénératives. Linvention concerne en outre des compositions pharmaceutiques et diagnostiques comportant le composé selon linvention ainsi quune trousse. Enfin, la présente invention concerne un procédé de formation dimages de dépôts de protéines agrégées ainsi quune trousse pour préparer un composé selon la présente invention marqué de manière détectable.
Bertsch Uwe
Frick Petra
Geissen Markus
Giese Armin
Griesinger Christian
Goudreau Gage Dubuc
Ludwig-Maximilians-Universitaet Muenchen
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.v.
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