New effectors of dipeptidyl peptidase iv for topical use

Details New effectors of dipeptidyl peptidase iv for topical use New effectors of dipeptidyl peptidase iv for topical use

C - Chemistry, Metallurgy

07

K

C07K 5/037 (2006.01) A61K 31/425 (2006.01) A61K 38/06 (2006.01) A61P 3/00 (2006.01) C07D 277/04 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) C07K 7/02 (2006.01) C07K 7/08 (2006.01) C08G 65/329 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2379875

The invention relates to compounds of general formula (I), wherein A represents an amino acid with at least one functional group in the side chain; while B is a chemical compound covalently bound to a functional group of the side chain of A, namely oligopeptide with a chain length of up to 20 amino acids with the exception of glycine homopolymers which have up to 6 glycine monomers or polyethylene glycols with molar masses of up to 20000 g/mole; C represents a thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine group which is amide bonded. These compounds can be used to topically influence the activity of dipeptidyl Peptidase IV.

L'invention concerne des composés de la formule générale (I) où A représente un acide aminé ayant au moins un groupe fonctionnel dans la chaîne latérale, B représente un composé chimique qui est lié de façon covalente à un groupe fonctionnel de la chaîne latérale de A, notamment des oligopeptides ayant une longueur de chaîne maximale de 20 acides aminés à l'exception des homopolymères de glycine composés de maximum 6 monomères de glycine ou polyéthylènglycols ayant des masses molaires de maximum 20000 g/mol, C représente un groupe thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, déhydroproline ou pipéridine qui est en liaison amide avec A. Ces composés peuvent être utilisés pour agir de façon topique sur l'activité de dipeptidylpeptidase IV.

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