C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/14 (2006.01) C12N 5/16 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2350334
This invention relates to a new member of a recently recognized TWIK potassium transport channels, herein designated as TASK2. TASK2 is a unique potassium transport channel which is regulated by external pH and predominantly expressed in kidney and epithelial tissues. The invention relates to various constructs of TASK2 for the production of TASK2 and their uses for diagnostic tests and screening methods to identify compounds that modulate potassium transport.
L'invention concerne un nouveau membre des canaux de transport de potassium TWIK récemment identifiés, appelés TASK2. TASK2 est un canal de transport d'un seul potassium régulé par un pH externe et exprimé essentiellement dans les tissus épithéliaux et rénaux. L'invention concerne aussi différentes constructions de TASK2 en vue de la production TASK2 et leurs application dans les tests diagnostiques et les procédés de criblage permettant d'identifier les composés qui modulent le transport de potassium.
Duprat Fabrice
Lazdunski Michel
Lesage Florian
Centre National de La Recherche Scientifique (c.n.r.s.)
Gowling Lafleur Henderson Llp
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