New fk-520 microbial transformation product

Details New fk-520 microbial transformation product New fk-520 microbial transformation product

A - Human Necessities

61

K

167/202, 260/228

A61K 31/455 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2016082

7503P/5304A 5/03/89:Fl 17911 TITLE OF THE INVENTION NEW FK-520 MICROBIAL TRANSFORMATION PRODUCT ABSTRACT OF THE DISCLOSURE Described is a new immunosuppressant, L-687,795, a C-13, C-15, C-31 trisdemethylated, ring rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, Actinoplanacete Sp. (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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