New foam-forming pharmaceutical composition

Details New foam-forming pharmaceutical composition New foam-forming pharmaceutical composition

A - Human Necessities

61

K

128/80

A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61K 31/606 (2006.01) A61K 45/00 (2006.01) A61M 5/178 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2302710

The invention provides a pharmaceutical composition for rectal ou vaginal administration which comprises at least two parts wherein the composition comprises (i) two or more physiologically acceptable substances each in separate parts of the composition which are such that on admixture they react to produce a physiologically acceptable gas; (ii) in at least one part of the composition a polymer stabiliser which is adapted to facilitate the formation of a water-soluble collapsible foam structure; and (iii) in at least one part of the composition a pharmaceutically active substance; and its use in a treatment or prophylaxis of disorders of the intestines, rectum or vagina.

L'invention concerne une composition pharmaceutique destinée à l'administration rectale ou vaginale et constituée d'au moins deux parties. Cette composition comprend (i) deux substances ou davantage, acceptables sur le plan physiologique, qui sont contenues dans les deux parties de la composition et qui, après mélange, réagissent de façon à produire un gaz acceptable sur le plan physiologique; (ii) dans au moins une partie de la composition, un stabilisant constitué d'un polymère, conçu pour faciliter la formation d'une structure mousseuse soluble dans l'eau et pouvant diminuer de volume; (iii) dans au moins une partie de la composition, une substance possédant une activité pharmaceutique. L'invention concerne également l'utilisation de ladite composition pour le traitement ou la prophylaxie des troubles de l'intestin, du rectum ou du vagin.

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