New form of amphiregulin, methods for producing and using...

Details New form of amphiregulin, methods for producing and using... New form of amphiregulin, methods for producing and using...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 14/485 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237543

The present information relates to the discovery of a new form of amphiregulin, referred to as AR97-187. The new form differs from the hitherto described amphiregulin forms in that it contains 4 additional amino acids at its N-terminal end. It also differs from already described forms with respect to its interaction with heparin in that its biological activity is only marginally reduced in the presence of heparin. Possibly, AR97-187 is produced by differentiating keratinocytes. AR97-187 is of therapeutical interest for the treatment of a variety of conditions, including wound healing, skin disorders and cancer.

La présente invention concerne la découverte d'une nouvelle forme d'amphiréguline, désignée par AR97-187. Cette nouvelle forme diffère des formes d'amphiréguline décrites jusqu'à présent, en ce qu'elle contient 4 acides aminés supplémentaires à son extrémité N-terminale. Elle diffère en outre des formes déjà décrites par son interaction avec l'héparine, à savoir son activité biologique n'est que très légèrement réduite en présence d'héparine. Il est possible de produire l'AR97-187 par différenciation de kératinocytes. L'AR97-187 présente un intérêt thérapeutique pour le traitement de divers états, par exemple pour la cicatrisation, les affections dermatologiques et le cancer.

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