New gamma selective retinoids

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 69/82 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61P 11/00 (2006.01) C07C 63/64 (2006.01) C07C 65/26 (2006.01) C07C 65/28 (2006.01) C07C 69/76 (2006.01) C07C 69/80 (2006.01) C07C 69/90 (2006.01) C07C 69/94 (2006.01) C07C 255/33 (2006.01) C07C 271/58 (2006.01) C07D 213/30 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 261/08 (2006.01) C07D 263/00 (2006.01) C07D 271/06 (2006.01) C07D 277/24 (2006.01) C07D 307/42 (2006.01) C07D 311/00 (2006.01) C07D 311/58 (2006.01) C07D 333/40 (200

Patent

CA 2407189

New RAR selective retinoid agonists of formula (I) wherein the symbols are as defined in the specification, and pharmaceutically active salts of carboxylic acids of formula (I), further the invention relates to the use of such retinoic acid receptor agonists, particularly retinoic acid receptor .gamma.(RAR.gamma.) selective agonists for the treatment of emphysema and associated pulmonary diseases, as well as for the therapy and prophylaxis of dermatological disorders, for the therapy and prophylaxis of malignant and premalignant epithelial lesions, tumours and precancerous changes of the mucous membrane in the mouth, tongue, larynx, oesophagus, bladder, cervix and colon.

L'invention concerne des agonistes rétinoïdes sélectifs de RAR de la formule I, dans laquelle les symboles sont tels que définis dans le descriptif, ainsi que des sels pharmaceutiquement actifs d'acides carboxyliques de la formule I. En outre, l'invention concerne l'utilisation de tels agonistes récepteurs d'acide rétinoïque, en particulier des agonistes sélectifs de récepteur .gamma. d'acide rétinoïque (RAR.gamma.), pour le traitement de l'emphysème et de maladies pulmonaires connexes, ainsi que pour la thérapie et la prophylaxie d'affections dermatologiques, de lésions épithéliales malignes et prémalignes, de tumeurs et de modifications précancéreuses de la muqueuse au niveau de la bouche, de la langue, du larynx, de l'oesophage, de la vésicule, du col utérin et du côlon.

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