New gdf-9 and gdf-9b (bmp-15) sequences for altering...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61P 15/00 (2006.01) C07K 14/475 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2490051

The present invention provides compositions and methods for modulating the ovulation rate and therefore fertility in female mammals including humans. The invention also relates to novel mutations in the GDF-9 and GDF-9B genes which are associated with changes in fertility.

L'invention concerne des compositions et des procédés permettant de moduler la vitesse d'ovulation et, par là même, la fertilité chez des mammifères femelles, et notamment chez la femme. Cette invention concerne également de nouvelles mutations dans les gènes GDF-9 et GDF-9B, lesquels sont associés à des modifications de la fertilité.

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