New haloalkylsulfone substituted compounds useful for...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/56 (2006.01) A61K 31/5355 (2006.01) A61P 3/04 (2006.01) C07D 261/08 (2006.01)

Patent

CA 2669860

The present invention relates to novel compounds of formula [I], wherein R1 represernts heteroaryl, at least one substituent among R5, R6 and R7 represent -SR12, -S(O)R12 or -S(O)2R12 and the remaining substituents are as defined in the claims, that act as chemical uncouplers. Compounds of the invention are useful inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases associated therewith.

Cette invention se rapporte à de nouveaux composés qui sont représentés par la formule [I], dans laquelle R1 représente hétéroaryle, au moins un substituant parmi R5, R6 et R7 représente -SR12, -S(O)R12 ou -S(O)2R12, les autres substituants étant tels que définis dans les revendications, et qui agissent comme découplants chimiques. Les composés de cette invention servent notamment à traiter, y compris à prévenir, l'obésité, le diabète et un certain nombre de maladies ou de troubles qui leur sont associés.

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