C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 39/395 (2006.01) A61P 31/14 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12N 15/867 (2006.01) C12Q 1/00 (2006.01) C12Q 1/70 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2739473
The human Occludin protein is identified as an essential Hepatitis C Virus (HCV) cell entry factor. Occludin is shown to render murine and other non-human cells infectable with HCV and to be required for HCV- susceptibility of human cells. Associated methods for inhibiting HCV infection, transgenic animal models for HCV pathogenesis, methods of identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin, and HCV inhibitory agents are also disclosed. Kits and cell culture compositions useful for identifying compounds or agents that prevent or mitigate interaction of HCV with Occludin are also provided.
Selon la présente invention, la protéine occludine humaine a été identifiée comme étant un facteur dentrée dans les cellules essentiel du virus de lhépatite C (VHC). Il a été démontré que loccludine rend les cellules murines et dautres cellules non humaines infectables par le VHC et est requise pour la sensibilité au VHC de cellules humaines. La présente invention concerne en outre des procédés associés pour inhiber linfection par le VHC, des modèles danimaux transgéniques pour la pathogenèse du VHC, des procédés didentification de composés ou agents qui préviennent ou atténuent linteraction du VHC avec loccludine, et des agents inhibiteurs du VHC. La présente invention concerne en outre des kits et des compositions de culture de cellules utiles pour identifier des composés ou agents qui préviennent ou atténuent linteraction du VHC avec loccludine.
Evans Matthew
Ploss Alexander
Rice Charles
Ridout & Maybee Llp
The Rockefeller University
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