C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/84 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61P 25/28 (2006.01) C07D 211/82 (2006.01) C07D 211/86 (2006.01) C07D 215/20 (2006.01) C07D 215/24 (2006.01) C07D 215/36 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2603345
The invention is related to compound which comprises at least one radical C=Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one carbon atom of the radical group C=Y and the nitrogen atom, when oxidized, is comprised between 0.3 and 0.8 nanometers. The invention is related to new heterocyclic compounds defined by formula G, their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of neurodegenerative or Alzheimer disease.
L'invention concerne des composés contenant au moins un radical C=Y, Y étant O ou S, et un atome d'azote N oxydable ou non protonable, la distance (d) entre le ou les atomes de carbone du groupe radical C=Y et l'atome d'azote, si oxydé, étant comprise entre 0,3 et 0,8 nm. L'invention concerne également de nouveaux composés hétérocycliques représentés par la formule G, leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en tant qu'agents thérapeutiques, notamment dans le traitement de maladies neurodégénératives ou de la maladie d'Alzheimer.
Bohn Pierre
Le Fur Nicolas
Levacher Vincent
Marsais Francis
Gous Inc.
Gowling Lafleur Henderson Llp
Insa Rouen
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