New heterocyclic oxime derivatives, their preparation...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/62 (2006.01) A61K 31/428 (2006.01) C07D 277/68 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2475137

The present invention concerns formula (I) compounds: (see formula I) where: ~ X represents an oxygen or sulfur atom, or a combination, CH2 or (see formule II) ~ R1, R2, R3, R4, R5 and R6 are as defined in the description, ~ A represents an alkylen chain as defined in the description, ~ B represents an alkyle or alkenyle group substituted by a grouping (see formula III) or R9, or B represents a grouing (see formula IV) or R9, ~ D represents a benzene ring, pyridine, pyrazine, pyrimidine or pyridazine, their enantiomers and diastereoisomers, as well their addition salts to an acide ou a pharmaceutically acceptable base. The invention also concerns the use of invention components as well as pharmaceutical compositions therein.

La présente invention concerne des composés de formule (I) : (voir formule I) dans laquelle : ~ X représente un atome d'oxygène ou de soufre, ou un groupement, CH2 ou (voir formule II) ~ R1, R2, R3, R4, R5 et R6 sont tels que définis dans la description, ~ A représente une chaîne alkylène telle que définie dans la description, ~ B représente un groupement alkyle ou alkényle substitués par un groupement (voir formule III) ou R9, ou B représente un groupement (voir formule IV) ou R9, ~ D représente un noyau benzénique, pyridinique, pyrazinique, pyrimidinique ou pyridazinique, leurs énantiomères et diastéréoisomères ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptables. L'invention concerne également l'utilisation des composés de l'invention ainsi que les compositions pharmaceutiques les contenant.

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