New human lymphotoxin n-end deletion mutant

Details New human lymphotoxin n-end deletion mutant New human lymphotoxin n-end deletion mutant

C - Chemistry, Metallurgy

12

N

530/13, 167/103.

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2001756

ABSTRACT OF THE DISCLOSURE HUMAN LYMPHOTOXIN The present invention provides N-terminal deletion mutants of human lymphotoxin which, through the lack of the first 27 amino acid residues characteristic of the naturally occurring molecule, exhibit greatly enhanced activity. Also provided are preparations, uses, methods of preparation, nucleic acid sequences, antibodies against, and preparations of the above human lymphotoxin N-terminal deletion mutants.

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