C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/5025 (2006.01) A61P 31/04 (2006.01) C07D 487/04 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2681393
The invention relates to Imidazolo-heteroaryl derivatives of formula (I). The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro.
L'invention porte sur des dérivés imidazolo-hétéroarylés de formule (I). Les composés inhibent l'activité de l'enzyme Dlta de bactéries Gram-positif et sont utiles pour traiter des infections bactériennes Gram-positif. De plus, la demande décrit un procédé pour évaluer l'activité inhibitrice de Dlta de molécules testées et un procédé pour mesurer l'efficacité de molécules dans l'inhibition de la prolifération de bactéries in vitro.
Bonvin Yannick
Denis Alexis
Escaich Sonia
Gerusz Vincent
Moreau Francois
Benoit & Cote Associes Inc.
Laboratoire Biodim
Mutabilis Sa
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