New indole derivatives with 5-ht6 receptor affinity

Details New indole derivatives with 5-ht6 receptor affinity New indole derivatives with 5-ht6 receptor affinity

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/4523 (2006.01) A61K 31/496 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2449874

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I), wherein one of R5, R6 or R7 is a group of general Formula (B), wherein W is a -CH- group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, their use as therapeutic agents, and methods of preparation thereof. (see formula I) (see formula B)

L'invention porte sur des composés, présentant une affinité générale pour les récepteurs 5-HT6, et de formule (I) dans laquelle: R<5>, R<6> ou R<7> est un groupe de formule générale (B) dans laquelle: W est un groupe CH ou un atome d'azote et les autres constituants sont: soit définis dans la description, soit des isomères individuels, soit des mélanges racémiques ou non racémiques d'isomères, ou leurs sels ou solvates pharmacocompatibles. L'invention porte également sur des préparations pharmaceutiques contenant lesdits composés, sur leur utilisation comme agents thérapeutiques, et sur leurs procédés d'obtention.

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