C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/22 (2006.01) A61K 31/553 (2006.01) A61P 35/00 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2377147
The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.
L'invention concerne des composés de la formule (1) ci-dessous, ou leurs sels acceptables sur le plan pharmaceutique, dans laquelle R<1> est un atome d'hydrogène, un groupe alkyle possédant 1 à 6 atomes de carbone ou un groupe alcoxy possédant 1 à 6 atomes de carbone; et ou R<2> est un atome d'hydrogène, un groupe alkyle possédant 1 à 6 atomes de carbone ou un groupe alcoxy possédant 1 à 6 atomes de carbone. L'invention concerne également: une méthode permettant d'obtenir ces composés; des compositions les contenant; ainsi que leur usage thérapeutique. Les composés de l'invention présentent une excellente activité contre les lignées cellulaires cancéreuses chez le mammifère.
Canedo Librada Maria
Espliego Fernando
Garcia Gravalos Dolores
Perez Julia
Romero Francisco
Instituto Biomar S.a.
Marks & Clerk
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