C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/14 (2006.01) A01H 5/00 (2006.01) A61K 39/145 (2006.01) A61P 31/16 (2006.01) C07K 14/11 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) A61J 1/05 (2006.01) A61M 5/178 (2006.01)
Patent
CA 2730668
A method for synthesizing influenza virus- like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of a novel influenza HA protein in plants and its purification The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding improved influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
La présente invention concerne un procédé pour synthétiser des particules de type influenzavirus (VLP) dans une plante ou une partie de plante. Le procédé met en uvre lexpression dune nouvelle protéine HA de la grippe dans des plantes et sa purification. Linvention concerne en outre une VLP comprenant la protéine HA de la grippe et des lipides de plantes. Linvention concerne en outre un acide nucléique codant pour HA de la grippe amélioré ainsi que des vecteurs. Les VLP peuvent être utilisées pour formuler des vaccins antigrippaux, ou peuvent être utilisées pour enrichir des vaccins existants.
Couture Manon
Landry Nathalie
Vezina Louis-Philippe
Gowling Lafleur Henderson Llp
Medicago Inc.
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