C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/75 (2006.01) A61K 31/10 (2006.01) A61K 31/16 (2006.01) A61K 31/167 (2006.01) A61K 31/351 (2006.01) A61P 11/00 (2006.01) C07C 259/10 (2006.01) C07C 309/39 (2006.01) C07D 309/10 (2006.01) C07H 15/203 (2006.01)
Patent
CA 2742920
The present invention relates in general to a compound which is characterized by a formula selected from the following formulas A, B, C, D, E or F: Image or a pharmaceutically acceptable salt thereof. The present invention further relates to pharmaceutical composition comprising the inhibitor(s) of the invention and to their use in the treatment of (for treating) a disease which is associated with an excess transport of hyaluronan across a lipid bilayer. The present invention furthermore relates to the use of at least one inhibitor of the invention for the preparation of a pharmaceutical composition for the treatment of (for treating) a disease which is associated with an excess transport of hyaluronan across a lipid bilayer. The present invention also relates to a method for manufacturing a pharmaceutical composition comprising the steps of formulating the inhibitor defined herein in a pharmaceutically acceptable form.
La présente invention concerne globalement un composé qui se caractérise par une formule sélectionnée parmi les formules A, B, C, D, E ou F; ou un sel pharmaceutiquement acceptable de ce dernier. La présente invention concerne également une composition pharmaceutique comprenant les inhibiteur(s) selon l'invention et leur utilisation dans le traitement (pour traiter une) d'une maladie qui est associée à un transport excessif de hyaluronane à travers une bicouche lipidique. Cette invention porte en outre sur l'utilisation d'au moins un inhibiteur selon l'invention pour préparer une composition pharmaceutique pour le traitement (pour traiter une) d'une maladie qui est associée à un transport excessif de hyaluronane à travers une bicouche lipidique. La présente invention concerne également un procédé de production d'une composition pharmaceutique comprenant les étapes de formulation sous une forme pharmaceutiquement acceptable, de l'inhibiteur défini dans cette invention
Blake Cassels & Graydon Llp
Universitaetsklinikum Muenster
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