New interferon beta-like molecules

Details New interferon beta-like molecules New interferon beta-like molecules

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/21 (2006.01) A61K 38/38 (2006.01) A61P 25/00 (2006.01) C07K 14/565 (2006.01) C07K 14/765 (2006.01) C07K 19/00 (2006.01) C12N 15/14 (2006.01) C12N 15/22 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2469846

The invention relates to a conjugate exhibiting interferon .szlig. activity and comprising at least one first non-polypeptide moiety covalently attached to an interferon .szlig. polypeptide, the amino acid sequence of which differs from that of wildtype human interferon .szlig. in at least one introduced and at least one removed amino acid residue comprising an attachment group for said first non-polypeptide moiety. The first non-polypeptide moiety is e.g. a polymer molecule or a sugar moiety. The conjugate finds particular use in therapy. The invention also relates to a glycosylated variant of a parent interferon .szlig. (IFNB) polypeptide comprising at least one <I>in vivo </I> glycosylation site, wherein an amino acid residue of said parent polypeptide located close to said glycosylation site has been modified to obtain the variant polypeptide having an increased glycosylation as compared to the glycosylation of the parent polypeptide.

L'invention concerne un conjugué présentant une activité d'interféron .szlig. et comprenant au moins un premier fragment non polypeptidique lié par covalence à un polypeptide interféron .szlig., dont la séquence d'acides aminés diffère de celle de l'interféron .szlig. humain sauvage dans au moins un reste d'acide aminé introduit et au moins un reste d'acide aminé éliminé comprenant un groupe de fixation pour ledit fragment non polypeptidique. Le premier fragment non polypeptidique est, par exemple, une molécule de polymère ou un fragment de sucre. Le conjugué est utilisé, en particulier, à des fins thérapeutiques. L'invention concerne également un variant glycosylé d'un polypeptide d'un interféron .szlig. parent (IFNB) comprenant au moins un site de glycosylation in vivo, dans lequel un reste d'acide aminé dudit polypeptide parent proche dudit site de glycosylation a été modifié pour obtenir le polypeptide variant dont la glycosylation est plus élevée que la glycosylation du polypeptide parent.

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