New interferon beta-like molecules

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 17/00 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) C07K 14/565 (2006.01) C07K 17/02 (2006.01) C07K 17/08 (2006.01) C07K 17/10 (2006.01) C12N 5/00 (2006.01) C12N 15/19 (2006.01) C12N 15/85 (2006.01) A61K 38/21 (2006.01)

Patent

CA 2380760

A conjugate exhibiting interferon .beta. activity and comprising at least one first non-polypeptide moiety covalently attached to an interferon .beta. polypeptide, the amino acid sequence of which differs from that of wildtype human interferon .beta. in at least one introduced and at least one removed amino acid residue comprising an attachment group for said first non- polypeptide moiety. The first non-polypeptide moiety is e.g. a polymer molecule or a sugar moiety. The conjugate finds particular use in therapy.

L'invention concerne un conjugué qui présente une activité d'interféron .beta. et contient au moins une première fraction non polypeptidique liée de manière covalente à un polypeptide d'interféron .beta., dont la séquence d'acides aminés diffère de celle de l'interféron .beta. humain de type sauvage par au moins un résidu d'acide aminé introduit et au moins un résidu d'acide aminé enlevé, y compris un groupe se fixant à ladite première fraction non polypeptidique. La première fraction non polypeptidique est par exemple une molécule polymère ou une fraction sucre. Le conjugué est particulièrement utile en thérapie.

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