New isocarbostyril alkaloid derivatives

Details New isocarbostyril alkaloid derivatives New isocarbostyril alkaloid derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/06 (2006.01) A61K 31/4355 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2665605

The present invention relates to novel isocarbostyril alkaloid derivatives having an anti-proliferative and anti-migratory activities, in particular to compounds of formula (I) or (II), stereoisomers, tautomers, racemates, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein R1, R2, R3, R4, R5, R6, and R7 have the same meaning as that defined in the claims. The present invention also relates to a method for the preparation of said compounds, to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds in the treatment and prophylaxis of cancer.

La présente invention concerne de nouveaux dérivés d'isocarbostyryl alcaloïde présentant des activités antiprolifératives et anti-migratoires, en particulier des composés représentés par la formule (I) ou (II), des stéréo-isomères, des tautomères, des racémates, des promédicaments, des métabolites de ceux-ci, ou un sel et/ou un solvate de ceux-ci acceptable du point de vue pharmaceutique, où R1, R2, R3, R4, R5, R6, et R7 ont la même signification que celle qui est définie dans les revendications. La présente invention porte également sur un procédé pour la préparation desdits composés, sur des compositions, en particulier des compositions pharmaceutiques comportant de tels composés, et sur des utilisations de tels composés dans le traitement et la prophylaxie du cancer.

Affiliated with

Also associated with

Rating

New isocarbostyril alkaloid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New isocarbostyril alkaloid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New isocarbostyril alkaloid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1707403