New isoxazole-sulfonamide endothelin antagonists

Details New isoxazole-sulfonamide endothelin antagonists New isoxazole-sulfonamide endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/42 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07D 231/52 (2006.01) C07D 261/16 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2348847

Isoxazoles of formula (I) below have good affinity for endothelin receptors, and are selective for ET A over ET B. (see formula I) Such compounds are useful in the treatment of conditions mediated by endothelin.

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