New lipophilic compositions and their uses

Details New lipophilic compositions and their uses New lipophilic compositions and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 31/664 (2006.01) A61K 31/7084 (2006.01) A61K 45/06 (2006.01) A61K 47/24 (2006.01) A61K 48/00 (2006.01) C07F 9/22 (2006.01) C07F 9/24 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 2701037

The invention relates to novel co-lipids that can be used in combination with lipophilic compounds used as nucleic acid vectors, for making a nucleic-acid vector composition. The invention also relates to nucleic-acid vector compositions containing a combination of (i) a nucleic-acid cationic lipohilic vector and (ii) a co-lipid. In some embodiments, the nucleic-acid vector compositions are in the form of unilamellar or multilamellar vesicles. The invention also relates to a method for the in vitro or in vivo insertion of a nucleic acid of interest into host cells, that comprises the step of contacting said host cells with a nucleic-acid vector composition as described above.

II est fourni selon l'invention de nouveaux co-lipides utilisables en combinaison avec des composés lipophiles vecteurs d'acides nucléiques, pour la fabrication d'une composition vecteur d'acides nucléiques. L'invention fournit aussi des compositions vecteurs d'acides nucléiques comprenant la combinaison (i) d'un vecteur lipophile cationique d'acides nucléiques et (ii) d'un co-li- pide. Ces compositions vecteurs d'acides nucléiques se présentent, dans certains modes de réalisation, sous la forme de vésicules unilamellaires ou multilamellaires. L'invention est également relative à des procédés pour introduire in vitro ou in vivo un acide nucléique d'intérêt dans des cellules hôtes, comprenant une étape de mise en contact desdites cellules hôtes avec une composition vecteur d'acides nucléiques telle que définie ci-dessus.

Affiliated with

Also associated with

Rating

New lipophilic compositions and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with New lipophilic compositions and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New lipophilic compositions and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1466486