C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/00 (2006.01)
Patent
CA 2597921
The present invention provides novel self-replicating and self-propagating chimeric viral vectors and chimeric virus particles comprising a modified genome of a carrier RNA virus packaged within structural proteins of a second virus. Also provided are pharmaceutical formulations comprising the chimeric viral vectors and virus particles and methods of inducing an immune response by administration of the same to a subject.
L'invention concerne de nouveaux vecteurs viraux chimères à autoréplication et autopropagation, et des particules virales chimères comprenant le génome modifié d'un virus à ARN porteur encapsidé dans des protéines structurales d'un second virus. L'invention concerne aussi des formulations pharmaceutiques comprenant ces vecteurs viraux chimères et particules virales chimères, et des procédés visant à induire une réaction immunitaire chez un sujet par l'administration desdites formulations.
Johnson Philip R.
Johnston Robert E.
Children's Hospital Inc.
Sim & Mcburney
University Of North Carolina At Chapel Hill
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