C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 25/02 (2006.01)
Patent
CA 2713776
The invention relates to macrolide compounds of formula (1),the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to processes for their preparation. The invention relates in particular to macrolide compounds with anti-inflammatory activity mediated primarily through inhibition of phosphodiesterase 4 (PDE4) which makes them useful for the treatment and/or prevention of inflammatory and allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, atopic dermatitis or inflammatory bowel disease or proliferative diseases such as cancer.
Linvention concerne des composés macrolides de formule (I), lutilisation desdits composés en tant que médicaments, notamment pour le traitement ou la prévention de maladies inflammatoires et allergiques, des compositions pharmaceutiques contenant lesdits composés et leurs procédés de préparation. Linvention concerne notamment des composés macrolides qui présentent une activité anti-inflammatoire médiée principalement par linhibition de la phosphodiestérase 4 (PDE4), ce qui les rend utiles pour le traitement et/ou la prévention de maladies inflammatoires et allergiques telles que la maladie pulmonaire obstructive chronique (COPD), lasthme, la polyarthrite rhumatoïde, la dermatite atopique ou la maladie intestinale inflammatoire, ou de maladies prolifératives telles que le cancer.
Dreier Juerg
Kellenberger Johannes Laurenz
Reinelt Stefan Bernhard
Basilea Pharmaceutica Ag
Gowling Lafleur Henderson Llp
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