New macrophages, process for preparing the same and their...

Details New macrophages, process for preparing the same and their... New macrophages, process for preparing the same and their...

A - Human Necessities

61

K

A61K 35/14 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/02 (2006.01) A61K 35/12 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2163218

The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-.gamma. is increased by about 20 to 30 % with respect to standard macrophages, and is preferably of about 70 %; their cytotoxic activity with IFN-.gamma. is increased by about 20 to about 40 % with respect to standard macrophages, and is preferably of about 93 %; the extension of the deactivation of the cytotoxic activity in reply to an activation of IFN-.gamma. is in a ratio such that after 60h of activation with IFN-.gamma., the cytotoxic activity is higher than or equal to 30 %, preferably of about 55 %, compared to the maximum cytotoxic activity presented by the macrophages due to IFN-.gamma. activation, with said cytotoxic activity being measured as the percentage of inhibition of 3-H thymidine incorporation by target tumoral cells, particularly U 937 cells.

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