New mandelic acid derivatives and their use as thrombin...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61P 7/02 (2006.01) C07C 45/00 (2006.01) C07C 45/29 (2006.01) C07C 45/51 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 59/56 (2006.01) C07C 59/64 (2006.01) C07C 69/732 (2006.01) C07C 69/734 (2006.01) C07C 69/738 (2006.01) C07C 205/59 (2006.01) C07D 207/16 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2456426

There is provided a compound of formula (I) and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compound and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin- like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

L'invention concerne un composé de la formule (I) et des dérivés pharmaceutiquement tolérables (y compris des promédicaments) de ce composé. Ce composé et ses dérivés sont utiles comme inhibiteurs compétitifs des protéases de type trypsine, telles que la thrombine, ou bien comme promédicaments de ces inhibiteurs. Ils s'avèrent donc utiles notamment dans le traitement d'états où l'inhibition de la thrombine est requise (par exemple, la thrombose) ou comme anticoagulants.

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