New medicaments based on polymers composed of...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 89/06 (2006.01) A61K 9/16 (2006.01) A61K 9/70 (2006.01) A61L 15/22 (2006.01) A61L 15/32 (2006.01) A61L 15/44 (2006.01) A61L 26/00 (2006.01) A61P 17/02 (2006.01) C08F 290/10 (2006.01) C08G 81/00 (2006.01) C08H 1/06 (2006.01) C08J 3/24 (2006.01)

Patent

CA 2290806

The present invention relates to a medicament comprising a biopolymer matrix comprising cross-linked vinyl-derivatives of gelatin, or co-polymerized methacrylamide modified gelatin with vinyl-modified polysaccharides, or cross- linked vinyl-substituted polysaccharide and gelatin being physically entrapped in a semi-interpenetrating network. Preferably said polysaccharide comprises dextran or xanthan. The present invention relates to a wound dressing or a controlled release device comprising said biopolymer matrix. Preferably said matrix is in the form of a hydrated film, a hydrated or dry foam, dry fibres which may be fabricated into a woven or non-woven tissue, hydrated or dry microbeads, dry powder, or covered with a semipermeable film, so as to control the humidity of the wound covered with the dressing, with the permeability chosen so as to maintain this humidity within a therapeutically optimal window.

La présente invention concerne un médicament comprenant une matrice de biopolymère contenant des dérivés vinyliques de gélatine réticulés, ou de la gélatine à modification méthacrylamide copolymérisée avec des polysaccharides à modification vinylique, ou une polysaccharide et de la gélatine à substitution vinylique, réticulées et physiquement piégées dans un réseau semi-enchevêtré. De préférence, la polysaccharide contient du dextrane ou du xanthane. La présente invention concerne un pansement pour plaies ou un dispositif à libération régulée comprenant la matrice de biopolymère. De préférence, la matrice est en forme de film hydraté, de mousse hydratée ou sèche, de fibres sèches pouvant être formées dans un tissu tissé ou non tissé, de microbilles hydratées ou sèches, de poudre sèche, ou alors la matrice peut être recouverte d'un film semi-perméable permettant de réguler l'humidité de la plaie recouverte par le pansement, la perméabilité étant sélectionnée de manière à maintenir cette humidité dans une gamme optimale du point de vue thérapeutique.

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