New method for dopamine measurement and diagnoses and...

G - Physics – 01 – N

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G01N 33/52 (2006.01)

Patent

CA 2581262

This invention relates to a new rapid and economical spectrophotometric method was applied for microdetermination of dopamine in pharmaceutical preparations and in urine samples of psychotic patients e.g. schizophrenic patients. This procedure depends on the formation of coloured complex between dopamine, copper sulfate and 4~aminoantipyrine under selected optimum conditions. The proposed procedure can be applied (1) to control the quantity of dopamine in pharmaceutical preparations (2) with psychiatric physician, which allows them to (a) detection the psychosis early which help in treatment and prevention of the disease e.g. screen study (b) diagnose of the disease (c) follow up the schizophrenic patients, (d) to control the dose of treatment and (f) prevention of relapse in patients on anti-psychotic drugs or with history of the disease.

La présente invention porte sur un nouveau procédé spectrophotométrique rapide et économique appliqué à la microdétermination de dopamine dans les préparations pharmaceutiques et dans les échantillons d~urine de patients psychotiques, par exemple des patients schizophrènes. Cette procédure dépend de la formation de complexe coloré entre la dopamine, le sulfate de cuivre et de la 4­aminoantipyrine dans des conditions optimales sélectionnées. La procédure proposée peut s~appliquer (1) au contrôle de la quantité de dopamine dans des préparations pharmaceutiques (2) avec l'assistance d'un psychiatre, ce qui permet de (a) détecter la psychose de façon prématurée, ce qui facilite le traitement et la prévention de la maladie, par exemple étude ciblée, (b) de diagnostiquer la maladie (c) d~effectuer un suivi des patients schizophrènes, (d) de contrôler la dose de traitement et (f) de prévenir la rechute chez les patients prenant des médicaments anti-psychotiques ou souffrant chroniquement de la maladie.

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