New method for salt preparation

Details New method for salt preparation New method for salt preparation

C - Chemistry, Metallurgy

07

C

C07C 209/74 (2006.01)

Patent

CA 2655061

The present invention provides a new method for preparation and crystallization of hydrochlorides, hydrobromides or hydroiodides of pharmaceutical compounds or their intermediates in which the base or its acid addition salt is reacted in a solvent with a Trialkylsilylhalogenide.

La présente invention concerne un nouveau procédé de préparation et de cristallisation des chlorhydrates, des bromhydrates ou des iodhydrates contenus dans des composés pharmaceutiques ou dans leurs intermédiaires. Dans ce procédé on fait réagir la base ou son sel d'addition d'acide dans un solvant avec un halogénure de trialkylsilyle.

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