New methods of making an antibody and compositions thereof

Details New methods of making an antibody and compositions thereof New methods of making an antibody and compositions thereof

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2758967

The present invention relates to new methods for making antibodies that involves chemically modifying the anti-gen with methylglyoxal. The present invention further relates to antibodies made in this manner, and include antibodies specific to LL-37. The present invention pertains to assays that utilize anti-LL-37 antibodies and assess compounds that stimulate LL-37 pro-duction. Such compounds are useful in antimicrobial compositions.

La présente invention concerne de nouveaux procédés pour préparer des anticorps qui mettent en uvre la modification chimique de l'antigène avec du méthylglyoxal. La présente invention concerne en outre des anticorps préparés de cette manière, et comprend des anticorps spécifiques de LL-37. La présente invention concerne des essais qui utilisent des anticorps anti-LL-37 et évaluent des composés qui stimulent la production de LL-37. De tels composés sont utiles dans des compositions antimicrobiennes.

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