New microbial immunoregulant

Details New microbial immunoregulant New microbial immunoregulant

C - Chemistry, Metallurgy

07

H

167/185, 260/228

C07H 17/00 (2006.01) A61K 31/455 (2006.01) C07H 19/01 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2012275

7410P/5413A 3/14/89:Fl 17888 TITLE OF THE INVENTION NEW MICROBIAL IMMUNOREGULANT ABSTRACT OF THE DISCLOSURE Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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