New microbial transformation product

Details New microbial transformation product New microbial transformation product

C - Chemistry, Metallurgy

12

P

167/229, 195/89

C12P 17/16 (2006.01) A61K 31/455 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2016084

7508P/5304A 5/04/89:F1 17863 TITLE OF THE INVENTION NEW MICROBIAL TRANSFORMATION PRODUCT ABSTRACT OF THE DISCLOSURE Described is a process for producing a new immunosuppressant, L-682,992, a C-13, C-31 demethylated ring-rearranged analog of L-679,934, under novel fermentation conditions utilizing the microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

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