A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/54 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/52 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2584417
An oral solid pharmaceutical dosage form comprising an acid sensitive proton pump inhibitor (PPI) as single active drug, releasing the PPI in two separate pulses, one immediate and one delayed. The PPI is formulated into a core material in the form of pellets, which are coated i.a. with a combination of a delayed release modifying layer and a lag time controlling layer. The pellets are further provided with an enteric coating layer. The application also relates to processes for preparing the dosage forms as well as their use in the treatment of gastrointestinal diseases.
L'invention concerne une forme de dosage pharmaceutique solide oral comprenant un inhibiteur de la pompe à protons (PPI) sensible à un acide comme médicament actif unique qui libère la PPI en deux impulsions séparées, l'une immédiate et l'autre retardée. La PPI est formulée dans un matériau de noyau sous forme de pastilles enrobées au moyen d'une combinaison de couche de modification de libération différée et de couche de commande de temps de latence qui ensemble fournissent des propriétés de libération bénéfiques. Les pastilles sont ensuite enrobées dans une couche de revêtement entérique. L'invention concerne également des procédés permettant de préparer les formes de dosage ainsi que des procédés d'utilisation permettant de traiter les maladies gastro-intestinales.
Clemmensen Niclas
Loefroth Jan-Erik
Walter Katrin
Wang Peter
Wikberg Martin
Astrazeneca Ab
Fetherstonhaugh & Co.
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