New mutational profiles in hiv-1 reverse transcriptase...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/70 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61P 31/18 (2006.01) C12Q 1/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2374215

The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, <i>i.e.</i>, drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.

L'invention concerne de nouvelles mutations, des combinaisons de mutations ou des profils mutationnels de la transcriptase inverse du VIH-1 et/ou des gènes de protéase, en relation à une résistance phénotypique aux médicaments anti-VIH. La présente invention concerne plus particulièrement l'utilisation d'une caractérisation génotypique d'une population de VIH cible et la corrélation conséquente entre ces informations et une interprétation phénotypique, et ce afin d'établir une relation entre les profils mutationnels du virus et la résistance aux médicaments. L'invention concerne également des procédés d'utilisation de ces profils mutationnels dans des bases de données, le développement de médicaments, c'est à dire leur conception, leur modification, la conception de thérapies et de traitements, le traitement clinique et l'analyse diagnostique.

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