New n-aryl and n-heteroarylamide and urea derivatives as...

Details New n-aryl and n-heteroarylamide and urea derivatives as... New n-aryl and n-heteroarylamide and urea derivatives as...

C - Chemistry, Metallurgy

07

D

167/211, 260/260

C07D 239/58 (2006.01) A61K 31/16 (2006.01) A61K 31/395 (2006.01) C07C 317/44 (2006.01) C07C 323/52 (2006.01) C07C 323/60 (2006.01) C07D 213/70 (2006.01) C07D 213/75 (2006.01) C07D 215/16 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 215/40 (2006.01) C07D 217/02 (2006.01) C07D 217/22 (2006.01) C07D 235/28 (2006.01) C07D 237/28 (2006.01) C07D 237/30 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 239/52 (2006.01) C07D 239/56 (2006.01) C07D 239/60 (2006.01) C07D 239/74 (2006.01) C07D 27

Patent

CA 2025301

Compounds of the formula (see formula I) the pharmaceutically acceptable salts thereof, wherein Q and R1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

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