C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/215 (2006.01) A61K 31/495 (2006.01) C07D 233/44 (2006.01) C07D 233/48 (2006.01) C07D 239/12 (2006.01)
Patent
CA 2333689
The invention relates to novel compounds of general formula (I) or the pharmaceutically acceptable salts thereof, wherein X = N-R3 or CH-R4, Y = CH2 or (CH2)2, Z = O or H2; and R1, R2, R3, R4 and Ar have the meaning cited in the description. The invention also relates to the production and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.
L'invention concerne de nouveaux composés de formule générale (I) ou leurs sels pharmaceutiquement acceptables. Dans la formule, X représente N-R?3¿ ou CH-R?4¿; Y représente CH¿2? ou (CH¿2?)¿2?; Z représente O ou H¿2?; et R?1¿, R?2¿, R?3¿, R?4¿ et Ar ont la signification indiquée dans la description. L'invention concerne également leur préparation et leur utilisation. Ces nouveaux composés constituent des antagonistes précieux de la neurokinine(tachykinine).
Dollinger Horst
Esser Franz
Jung Birgit
Luttke Sven
Schnorrenberg Gerd
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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