New nitromethyl ketones, process for preparing them and...

Details New nitromethyl ketones, process for preparing them and... New nitromethyl ketones, process for preparing them and...

C - Chemistry, Metallurgy

07

C

C07C 205/45 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) C07C 225/22 (2006.01) C07C 233/33 (2006.01) C07C 233/61 (2006.01) C07C 233/76 (2006.01) C07C 235/24 (2006.01) C07C 235/38 (2006.01) C07C 235/56 (2006.01) C07C 237/22 (2006.01) C07C 255/56 (2006.01) C07C 311/21 (2006.01) C07C 311/60 (2006.01) C07C 317/24 (2006.01) C07C 323/22 (2006.01) C07D 209/48 (2006.01) C07D 211/76 (2006.01) C07D 307/84 (2006.01) C07D 333/20 (2006.01) C07D 333/22 (2006.01) C07D 333/56 (2006.01) C07D 333/62 (2006.01) C07D 333

Patent

CA 2290831

The compounds of formula (I) in which: A represents C6-C10 aryl or an optionally aromatic three- to ten-membered heterocycle; X represents halogen, cyano, C1-C7 alkyl, trifluoromethyl, C2-C7 alkoxy or trifluoromethoxy; p is chosen from 0, 1, 2, 3, 4 and 5; Z represents a bond, -CO-NH-, -SO2-NH-, C2-C7 alkenylene, sulfur, sulfinyl, or sulfonyl; n represents 0 or 1; R1, R2, R3, E, are as defined in Claim 1, are aldose reductase inhibitors.

L'invention concerne des composés de formule (I) dans laquelle A désigne aryle C¿6?-C¿10? ou un hétérocycle éventuellement aromatique ayant entre trois et dix chaînons; X désigne halogène, cyano, alkyle C¿1?-C¿7?, trifluorométhyle, alcoxy C¿2?-C¿7? ou trifluorométhoxy; p est sélectionné entre 0, 1, 2, 3, 4, et 5; Z désigne une liaison, -CO-NH-, -SO¿2?-NH-, alcénylène C¿2?-C¿7?, soufre, sulfinyle ou sulfonyle; n vaut 0 ou 1; R¿1?, R¿2?, R¿3?, E ont la signification mentionnée dans la revendication 1 et sont des inhibiteurs de la réductase aldose.

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